What happens if you join this study?
You will meet with a lung cancer doctor who is an ALCMI CASTLE study doctor, and members of his or her research team. They will explain the study.

If you agree to participate in the study, the procedures are as follows:

• You will be asked to give samples from a biopsy (a tissue sample from your tumor). You will be asked to participate in this study only if you have already had a biopsy, or are having a planned biopsy or surgery. You will not be asked to have a biopsy or surgery only to qualify for or participate in this study.

• At study entry, you will be asked about your health and cancer history, current medications, smoking history, toxic exposure history, and your family history of cancer. You will also be asked to give about 36 milliliters, or a little more than 7 teaspoons, of blood for testing and research. This visit will take about one hour to complete.

• Every time there are changes in your lung cancer treatments you will be asked to give about 19 milliliters, or almost 4 teaspoons, of blood for research purposes. You will also be asked about your current and recent medications, and any cancer treatments at these visits. Each visit will take about 30 minutes to complete.

• You will be asked to give your study doctor and his or her research team permission to contact you or your family every 3 months and/or if your cancer treatment changes. They will ask you about your health and your treatment.